For pharmaceutical rubber bottle stoppers, rubber is an indispensable material. The quality of raw rubber has a great influence on the quality of medicines. Therefore, choosing the correct raw rubber is a guarantee for improving the quality of medicines. Natural rubber bottle stoppers have many problems in drug packaging. The presence of protein, organic and inorganic substances in natural rubber causes adverse drug allergic reactions. Natural rubber is non-polar rubber, so it only It can withstand some polar solvents, but in non-polar solvents, it is prone to swelling and other intolerant phenomena, so it is not resistant to oil and non-polar solvents.
The shortcomings of natural rubber bottle stoppers are summarized as follows: (1) Poor airtightness (2) Poor chemical resistance (3) Poor aging resistance (4) Poor high temperature and radiation resistance (5) Poor weather resistance (6) It is not easy to contain more The separated protein and other substances are more, and its purity is low.
The main component of butyl rubber is polyisobutylene. However, the methyl group in polyisobutylene has large steric obstacles, so the thermal motion of the molecules is not active, so its gas permeability is min in synthetic rubber, and the molecular double bond It has a small number in the main chain, so it has very good UV resistance, ozone resistance and weather resistance, and also high heat resistance. In addition, butyl rubber is non-polar, so it has good resistance to polar solvents, so it can give medicines good chemical stability.
The advantages of butyl rubber bottle stoppers are summarized as follows: (1) It has good air tightness and small air permeability. (2) Very good high temperature resistance. (3) Good ozone resistance and weather resistance. (4) Alkali and acid medium solvents. (5) Poor water absorption and good radiation resistance.